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Open access Sep 2026

Paeoniflorin restores redox homeostasis in oxidatively challenged C2C12 myoblasts via activation of the Nrf2/HO-1 pathway

Oxidative stress is a key contributor to myoblast injury and disrupts musculoskeletal homeostasis by impairing muscle differentiation. Paeoniflorin, a bioactive monoterpene glycoside derived from medicinal plants, e.g., Paeonia lactiflora, has demonstrated diverse pharmacological activities. This study explored paeonif...

Cheol Park, E. Bang, Chengrong Jin et al. · 0 citations
Jul 2026

Luteolin reverses chemoresistance in colorectal cancer cells via TET1/TDG-dependent epigenetic repression of β-catenin.

Resistance to 5-fluorouracil (5-FU) and oxaliplatin (OXT) remains a major cause of treatment failure in colorectal cancer (CRC). Luteolin, a dietary flavonoid with anticancer properties, has shown therapeutic potential in various malignancies, but its effects on chemotherapy-resistant CRC remain poorly understood. In t...

K. Kang, Mei-Jing Piao, H. Senavirathna et al. · 0 citations

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