The therapeutic efficacy of interferon alpha (IFNα) is well-established in various conditions, including Hepatitis B and C, lymphoma and skin cancer, attributed to its potent angiostatic, immunomodulatory, and antiproliferative properties. Clinical applications using this bioactive are, however, hindered by systemic to...
Magdi Abobaker, Mershen Govender, Y. Choonara· AAPS PharmSciTech· 0 citations
Exosomes are nanoscale vesicles derived from cell membranes with crucial roles in physiological and disease-specific processes. EVs may offer biological compatibility and cell-interactive surfaces, but these properties are source-, process-, cargo-, and route-dependent and should not be assumed to be superior to liposo...
Y. Choonara, K. Mnqiwu, M. Chougule et al.· International journal of pha...· 0 citations
Neurological disorders (NDs) are characterized by substantial loss of specific neurons, with Alzheimer's and Parkinson's diseases being the most frequent NDs and nearly 99% of all “foreign substances” are prohibited from entering the brain by the blood‐brain barrier (BBB) and the blood‐cerebrospinal fluid barrier (CFB)...
N. I. Okafor, Ahmed Abdelgader, Magdi Abobaker et al.· ChemistryOpen· 0 citations
An injectable sonodynamic hydrogel (POPP gel) that captures bacteria via a nanofibrous cationic network and kills them upon ultrasound activation is developed, which reduces bacterial burden and accelerates tissue repair in murine infected wound and burn models.
Yongchang Tian, Rong Zhang, Xing-Jun Zhao et al.· Acta Biomaterialia· 0 citations
A translational framework for overcoming key barriers in pharmaceutical intervention design for oncology applications is outlined, integrating drug delivery engineering, molecular biopharmaceutics, and computational optimization.
Manoj Dalabehera, Shubham K. Chaudhari, Jatin Kumar et al.· Journal of Pharmacy and Scie...· 0 citations
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