Pentagalloylglucose induces ferroptosis-related cell death by disrupting lipid homeostasis through the let-7a-5p/LIN28B/SREBP1 axis in colorectal cancer.
Colorectal cancer (CRC) is characterized by metabolic reprogramming, including lipid accumulation, which promotes tumor progression and resistance to cell death. Although 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG) has reported anticancer effects, its effects on lipid metabolism and ferroptosis-related cell death in CR...