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Author

Y. J. Zhang

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Review Open access Aug 2026

Communication is key: combinatorial phosphorylation and functional cross-talk in the RNA polymerase II CTD code

The hierarchical transitions between phosphorylation states are explored, highlighting how combinatorial marks rather than isolated modifications shape transcriptional progression and prevent cryptic initiation through cross-talk with the histone code.

Y. J. Zhang, Erin L. Ramsey · 0 citations
Open access Jul 2026

Using enantioselective biosensors to evolve asymmetric biocatalysts.

This work evolves enantioselective transcription factors that convert enzyme-catalyzed enantiomer concentrations into programmable gene expression outputs, focusing on imine reductases, and designs a genetic circuit that enables TF generation within weeks.

Simon d’Oelsnitz, Wantae Kim, Nicole N Zhao et al. · 7 citations

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