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Open access Sep 2026

Mitochondrial Phosphatase PGAM5 Negatively Regulates the Induction of Anti-inflammatory Macrophages.

Macrophage polarization toward anti-inflammatory phenotypes is essential for the resolution of inflammation and restoration of tissue homeostasis, yet the mitochondrial mechanisms governing this process remain poorly defined. This study identifies a novel role for the mitochondrial membrane protein, phosphoglycerate mu...

Y. Kang · 0 citations
Open access Jul 2026

4-1BBL Suppresses Anti-Inflammatory Responses by Regulating Metabolic Reprogramming of Macrophages.

Integration of intracellular signalling and metabolic reprogramming is critical for macrophage polarisation and the induction of pro- or anti-inflammatory responses. However, the molecular switches that govern these processes remain incompletely defined. While 4-1BB ligand (4-1BBL), a member of the TNF superfamily, is...

Y. Kang · 0 citations

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