Terminal erythroid differentiation involves dramatic cellular remodeling that culminates in the expulsion of the nucleus, a process known as enucleation. While enucleation is conserved across mammals and is crucial for the generation of fully functional erythrocytes, the mechanisms governing this process have remained...
Marilou Tétard, Tian Lin, N. Peterson et al.· American journal of hematolo...· 0 citations
CIT-Lasso, a framework that uses only summary statistics to identify, genome-wide, sets of variants carrying non-redundant information on a phenotype, distinguishing likely causal variants from correlated variants that are merely associated, outperforms existing methods in false discovery rate control, power, and fine-...
Zi-Huai He, Benjamin B. Chu, James Yang et al.· Genome Biology· 0 citations
By distinguishing diagnostic-state markers from progression-linked changes, this longitudinal, multi-domain approach prioritizes proteins for validation as markers of AD progression and for mechanistic and therapeutic follow-up.
Junyoung Park, Y. le Guen, A. Peña-Tauber et al.· medRxiv· 0 citations
Although a two-cluster solution was reproducible, separation was weak and added little clinical information beyond the continuous axes, and Plasma proteomics did not support robust Alzheimer's disease subtypes.
Routine and accessible plasma measures can be leveraged to recover reproducible, biologically distinct progression modules that improve characterization of heterogeneous AD and have practical value for risk stratification, trial enrichment, or treatment monitoring.
R. R. Butler, M. Brown, A. Weber et al.· medRxiv· 1 citation
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