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Author

Y. Li

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Open access Oct 2026

Carnitine acetyltransferase (CrAT)-Solute Carrier Family 25 Member 20 (SLC25A20) mediated acetylcarnitine shuttle links lipid oxidation to epigenetic control of cardiac metabolic maturation

During postnatal development, cardiomyocytes experience marked upregulation of lipid metabolism genes, which drives the transition from glycolysis to fatty acid β-oxidation (FAO). Fatty acids (FA) insufficiency hinders the maturation of induced pluripotent stem cell-derived cardiomyocytes, yet the underlying mech...

D. Guo, L. Hu, Y. Li · 0 citations
Open access Oct 2026

Pyruvate metabolism enzyme Dlat induces mitochondria protein hyperacetylation to limit fatty acid oxidation in the HFpEF heart

Myocardial metabolic impairments were known to play a significant role in the development of heart failure with preserved ejection fraction (HFpEF), while the pathogenic mechanisms remain largely unknown. Increased protein acetylation was frequently detected in the failing heart including HFpEF hearts. Nonetheles...

Y. Wang, Y. Li, L. Hu · 0 citations

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