Abstract A050: NEIL2 regulates RNA polymerase II dynamics to suppress transcription–replication conflicts in pancreatic cancer
Transcription–replication conflicts (TRCs), arising from spatiotemporal interference between transcription and replication machinery, are major sources of genome instability in cell. In pancreatic ductal adenocarcinoma (PDAC), oncogenic KRAS promotes TRC formation, and pharmacological exacerbation of endogenous T...