Y. Mustafa

From Bench to Algorithms: Artificial Intelligence Applications in the Chemical Engineering of Coumarin-Based Therapeutics

Problem: Coumarin derivatives exhibit broad pharmacological activities and substantial therapeutic potential, yet the integration of artificial intelligence (AI)with chemical engineering across their discovery, synthesis, optimization, and pharmaceutical manufacturing remains fragmented. Aim: This review critically eva...

Natural and Synthetic Coumarins as Tumor Microenvironment-Oriented Immunotherapeutic Agents: A Review

The tumor microenvironment (TME) plays a major role in cancer progression, immune evasion, and resistance to immunotherapy. Coumarins, a structurally diverse class of natural and synthetic compounds, have attracted increasing attention because of their anticancer, anti-inflammatory, antioxidant, and immunomodulatory pr...

Coumarins in hypertension management: from vascular signaling pathways to clinical perspectives.