Author

Y. Orba

4 papers indexed here

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Open access Sep 2026

Reverse genetics system for emerging tick-borne orthonairovirus highlights dispensable N-terminal region of Gn associated with replication in tick vectors

A growing number of emerging and re-emerging tick-borne orthonairoviruses belonging to the Sulina and Tamdy genogroups have recently been identified in association with febrile diseases in East Asia. Yezo virus (YEZV) is one such viruses and is genetically distinct from well- characterized Crimean-Congo hemorrhagic fev...

Yume Mimura, Takahiro Hiono, H. Arakawa et al. · bioRxiv · 0 citations

Open access Aug 2026

Lassa fever and Argentine hemorrhagic fever treatment in guinea pigs using broad-spectrum cap-dependent endonuclease inhibitors

ABSTRACT The class Bunyaviricetes encompasses several highly pathogenic viruses that cause lethal hemorrhagic fevers. Due to their limited prevention and treatment options and high pathogenicity, these viruses require handling in biosafety level-4 facilities. Within the bunyaviruses, arenaviruses are particularly notab...

Junki Maruyama, Satoshi Taniguchi, Takeshi Saito et al. · mBio · 0 citations

Open access Aug 2026

Interleukin-34 Promotes Activation of Disease-associated Microglia-like Cells and Attenuates Disease Progression in West Nile Virus Infection

West Nile virus (WNV) is a mosquito-borne orthoflavivirus that causes severe encephalitis, for which no approved antiviral therapies or human vaccines are currently available. Disease-associated microglia (DAM) represent a microglial state associated with neuroprotective functions in neurodegenerative diseases. We prev...

Passawat Thammahakin, Keisuke Maezono, T. Dương et al. · bioRxiv · 0 citations

Open access Aug 2026

Genomic signatures of native (Japanese) and introduced (Oceanian) populations of the Asian longhorned tick Haemaphysalis longicornis

Abstract The Asian longhorned tick (Haemaphysalis longicornis) impacts the health of humans, livestock, and wildlife, both as a parasite and a vector. Over more than a century, H. longicornis has become a widespread invasive species across much of the Asia-Pacific region, with a recent emergence in North America. This...

Y. Ohari, Kodai Kusakisako, Mackenzie L. Kwak et al. · PNAS Nexus · 0 citations