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Author

Y. Pijnenburg

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5 papers indexed here

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Open access Aug 2026

Carrying specific HLA alleles decreases the chance of reaching healthy old age

Human leukocyte antigen ( HLA ) genes regulate immune function and influence disease susceptibility, but their role in healthy aging is unclear. We investigated whether disease-associated HLA alleles affect the likelihood of becoming a cognitively healthy centenarian (CHC). Using imputed HLA genotypes from 36...

D. A. Sirvent, N. Tesi, M. Hulsman et al. · 0 citations
Open access Sep 2026

Conceptualizing cognition and behaviour across amyotrophic lateral sclerosis and frontotemporal dementia.

Cognitive and behavioral dysfunction in frontotemporal dementia (FTD) evolves along a clinical continuum from a clinically silent stage of disease, through a prodromal period, often referred to as mild cognitive impairment (MCI) and/or mild behavioral impairment (MBI), and into a clinically manifest stage recognized by...

M. Benatar, E. Huey, Chiadikaobi Onyike et al. · 1 citation
Open access Aug 2026

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

The model’s accurate estimation of disease stages underscores the value of DEBM for patient stratification, offer a promising tool to support clinical trial design and provide a temporal ordering of multiple CSF proteins.

J. D. De Houwer, Wenjie Kang, Renee van Buuren et al. · 0 citations
Open access Sep 2026

APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers’s disease

Understanding of the genetic architecture of AD in the context of its main genetic driver is improved, and APOE-stratified insights may help understand and overcome side effects, inform clinical trial enrollment strategies, and create the scientific basis for targeted, mechanism-driven therapies in neurodegenerative di...

J. Thomassen, H. Leonard, Brittany Ulms et al. · 0 citations
Open access Aug 2026

Educational attainment and sex modulate clinical outcomes in genetic frontotemporal dementia

Sex and educational attainment significantly affect the development and maintenance of cognitive reserve in individuals with genetic FTD, and underscore the importance of identifying disease-modifying interventions since the presymptomatic stages of the disease.

E. Premi, Damiano Archetti, A. Redolfi et al. · 0 citations

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