Evaluation of CTA1-DD and trimethyl chitosan-based particles for intranasal immunization with tandem-repeat SARSCoV-2 spike epitopes: An exploratory study in mice
Background: Epitope-based vaccines offer a non-replicating, compositionally defined approach to mucosal immunization against respiratory pathogens but are generally less immunogenic than live attenuated vaccines. In previous studies, we developed the SARS-CoV-2 spike epitopes S14P5 and S21P2 as tandem-repeat construct...