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Author

Y. Sasamoto

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Sep 2026

Inhibition of PLK1 helps to restrict c-Met-induced growth and therapeutic resistance of renal cancer cells.

Acquired therapeutic resistance is a major problem in the treatment of advanced renal cell carcinoma (RCC). The receptor tyrosine kinase (RTK) c-Met is hyperactive in RCC and plays a major role in the survival of tumor cells during therapy-induced oxidative stress. Although c-Met/RTK inhibitor, cabozantinib (cabo), has...

S. Pal, L. Rawat, Chiranth M. Prakash et al. · 0 citations

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