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Review Open access Oct 2026

Epigenetic aging in the tumor microenvironment: mechanisms and implications for immunotherapy

Aging reshapes the tumor microenvironment (TME) by altering the immune, stromal, and vascular compartments, yet these changes are not fully explained by chronological age. Epigenetic mechanisms, including DNA methylation, histone modifications, chromatin accessibility, and non-coding RNA programs, may contribute to per...

Fusako Takezawa, Y. Sato · 0 citations

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