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Open access Sep 2026

Serotonergic Transmission in the Hippocampus Is Subject to Multifaceted Modulation by Other Neurotransmitters

Purpose Serotonin (5-HT) release in the hippocampus is modulated by N-methyl-D-aspartate (NMDA) receptor activity, particularly under hypoxic conditions, but the roles of other neurotransmitter systems remain unclear. This study examined how several neurotransmitters affect spontaneous 5-HT release in rat hippocampal s...

Jae Heon Kim, Mi-Ho Song, Chan-Young Lee et al. · 0 citations
Open access Sep 2026

MT-Exo-derived miR-4651 and miR-6126 coordinately regulate the SRSF1-progerin and SP1-PrPᶜ axes to attenuate vascular aging in HGPS.

Hutchinson-Gilford progeria syndrome (HGPS) is characterized by progressive vascular injury that remains incompletely controlled by therapies targeting progerin-associated pathology. Here, we investigated the therapeutic activity and molecular mechanisms of melatonin-preconditioned mesenchymal stromal cell-derived smal...

E. Joo, Unyoung Yoon, Jaeyoung Lee et al. · 0 citations
Review Open access Sep 2026

Context-Dependent PrPᶜ Signaling in Cancer Stemness, Mesenchymal Stromal Cell Repair, and Extracellular Vesicle Biology.

Cellular prion protein (PrPᶜ), encoded by PRNP, is increasingly recognized as a context-dependent regulator of cellular stress adaptation and intercellular communication beyond its canonical role as the physiological precursor of disease-associated prion conformers. Through its localization in membrane microdomains and...

Sang-Hun Lee, Y. Song · 0 citations

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