Author

Y. Tan

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Open access Oct 2026

Antibody 3CF5 neutralizes historical and emerging H5Nx influenza viruses by targeting a conserved non-receptor-binding hemagglutinin epitope.

Avian influenza viruses of the H5Nx subtype pose persistent pandemic threats. Here, we immunized rhesus macaques with an H5N6 vaccine and obtained 30 H5-reactive monoclonal antibodies (mAbs). Three IgG mAbs, 3CF5, 3BG3, and 3BE7, demonstrated potent neutralizing activity against multiple H5Nx viruses and conferred prot...

Huan Liang, Chuan-Ying Niu, Yuan-Yi Cheng et al. · Cell Reports · 0 citations

Review Open access Aug 2026

Population Immunity to Influenza Neuraminidase: From Immune Imprinting to Pandemic Preparedness

Neuraminidase (NA) is a major surface glycoprotein of influenza viruses that mediates the release of progeny virions from infected cells. Although both hemagglutinin (HA) and NA are targets of protective immune responses, current seasonal influenza vaccines are primarily standardized based on HA content, resulting in v...

Kong Yen Liew, T. K. Sari, Y. Tan · Vaccines · 0 citations