Pyruvate metabolism enzyme Dlat induces mitochondria protein hyperacetylation to limit fatty acid oxidation in the HFpEF heart
Myocardial metabolic impairments were known to play a significant role in the development of heart failure with preserved ejection fraction (HFpEF), while the pathogenic mechanisms remain largely unknown. Increased protein acetylation was frequently detected in the failing heart including HFpEF hearts. Nonetheles...