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Author

Y. Xia

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Open access Oct 2026

Single-cell transcriptomic landscape of psoriasis-accelerated atherosclerosis reveals immune remodeling and macrophage dysfunction

Psoriasis, a chronic inflammatory skin disease, confers a significantly increased risk of atherosclerosis and cardiovascular events. However, the cellular and molecular mechanisms underlying this accelerated atherosclerosis remain poorly understood at single-cell resolution. We performed single-cell RNA se...

F. Tan, R. Wang, Y. Jiang et al. · 0 citations
Review Oct 2026

Liver-specific sustained activation of the LPS/TLR4/NF-κB pathway: from a gut-liver axis hub to cascading extensions in reproductive and neuroinflammation.

The chronic activation of the hepatic lipopolysaccharide (LPS)/toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) pathway, which links intestinal dysbiosis, chronic hepatic inflammation, and injury to other organs, is a crucial mechanism of pathogenesis in the gut-liver axis. Intestinal barrier disruption facilitate...

Yang J. Xia, Li Zheng, Zi-Mi Li et al. · 0 citations

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