DNA-functionalized nanoparticle (DNA–NP) superlattices have attracted attention as programmable nanomaterials for sensing and bio-related applications, because DNA hybridization enables programmable interactions between nanoparticles and thus control of interparticle spacing. Such applications require controlling the s...
Saki Kozawa, Hiroya Arai, Xu Li et al.· Journal of Robotics and Mech...· 0 citations
DNA nanomachines based on gold nanoparticles (AuNPs) are promising platforms for intracellular sensing of microRNAs (miRNAs), which are biomarkers involved in a wide range of diseases. However, achieving robust performance under intracellular conditions remains challenging. In this study, we investigated the effect of...
M. Yokomori, Keitaro Yoshimoto, Y. Yamanishi· Journal of Robotics and Mech...· 0 citations
Cell-laden alginate microgels have been extensively studied for three-dimensional cell culture, tissue engineering, and cell-based screening because they provide microscale compartments that support cell culture in a defined microenvironment. In particular, single-cell-laden alginate microgels have attracted increasing...
Hiroki Fukunaga, Naotomo Tottori, S. Sakuma et al.· Journal of Robotics and Mech...· 0 citations
Engineered cells incorporating synthetic gene circuits have been developed for therapeutic and diagnostic applications. However, cell proliferation and long-term engraftment may pose a risk of unpredictable toxicities. To address this issue, a suicide switch that can be selectively activated by exogenous stimuli has...
Satoshi Yoshimoto, Shigeo S. Sugano, S. Sakuma et al.· ACS Synthetic Biology· 0 citations
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