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In a KYSE510 xenograft model, oral administration of JH-1 significantly suppressed tumor growth without obvious toxicity and validate the quinazoline scaffold for epigenetic cancer therapy.
This review delves into exosome isolation techniques, the regulatory mechanisms underlying their biogenesis and secretion, and their dual roles in cancer progression, metastasis, and tumor immunity, concluding with a discussion of the challenges and future directions in their clinical translation.
Nine previously undescribed prenylated xanthones, aspxanthones A-I (1-9), were isolated and characterized from the endophytic fungus Aspergillus sp. TJ507. Their structures were established through comprehensive spectroscopic analyses, single-crystal X-ray diffraction, and DP4+ probability analysis. Compounds 1, 2, and...
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