Ya-Jie Shi

Design, Synthesis and Antitumor Activity Evaluation of Novel Dual G9a/EZH2 Inhibitors

Targeting the crosstalk between histone methyltransferases G9a and EZH2 represents a promising strategy for cancer therapy. To improve upon our previously reported dual inhibitor SU08, we rationally designed and synthesized five series (SU, UA, UB, N, and L) of novel G9a/EZH2 dual inhibitors, incorporating diverse pyri...