Ya-Jing Gao

Design and structural basis of selective nonsteroidal inhibitors of aster cholesterol trafficking

Significance Cholesterol transport by Aster proteins from the plasma membrane (PM) to the endoplasmic reticulum is important for cholesterol homeostasis. We identify nonsteroidal Aster inhibitors with improved specificity and reduced toxicity compared to sterol-based inhibitors. YKJ-124, a low-toxicity Aster-A preferri...