Open access
Sep 2026
Squalene alleviates DSS-induced colitis by restoring Nrf2-dependent redox balance and gut microbiota homeostasis
Background Ulcerative colitis (UC) is a chronic inflammatory disorder characterized by excessive oxidative stress, intestinal epithelial barrier dysfunction, and gut microbiota dysbiosis; despite expanding therapeutic options, achieving durable disease control remains challenging. Squalene (SQ), a naturally occurring t...
Peng Jiang, Z. Ling, Shuo Han et al.
· Frontiers in Pharmacology · 0 citations