Author

Ya-Kun Wang

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Open access Oct 2026

A DNA G-Quadruplex-Targeting Ligand Suppresses c-MYC Expression: Implications for Gemcitabine‑Resistant Pancreatic Cancer.

The MYC oncogene is dysregulated in nearly 70% of human cancers and plays a central role in tumor initiation and progression. However, direct targeting of c-MYC remains challenging because of its "undruggable" nature. Stabilization of DNA G-quadruplex (G4) structures within the c-MYC promoter offers an alternative stra...

Bo-Xin Zheng, Ya-Kun Wang, Ze-Xin Chen et al. · Angewandte Chemie · 0 citations

Aug 2026

Photodynamic activity of a mitochondria-localized G-quadruplex-responsive fluorescent ligand: Cellular effects and photo-enhanced cytotoxicity.

Mitochondrial localization concentrates photosensitizing molecules near redox-sensitive organelles. In this study, we investigated SPN, a mitochondria-targeted G-quadruplex (G4)-responsive ligand. Photochemical characterization confirmed that SPN generates robust light-triggered ROS and exhibits photooxidative activity...

Ya-Kun Wang, Jia-Peng Dong, Hongshan Xie et al. · Spectrochimica Acta Part A -... · 0 citations