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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Ya Li

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Sep 2026

Enantioselective Michael addition of N-substituted 3-chlorooxindoles with 1,1-bis(arylsulfonyl)ethylenes: access to 3,3-disubstituted and spirocyclopropane-fused oxindoles.

We report a highly enantioselective organocatalyzed Michael addition of N-substituted 3-chlorooxindoles to 1,1-bis(arylsulfonyl)ethylenes. With a readily available quinine-derived catalyst under mild conditions, this reaction delivers chiral 3,3-disubstituted oxindoles in high yields (up to 93%) and enantioselectivitie...

Siyuan Wan, You-Can Zhang, Ling-Yan Chen et al. · 0 citations

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