Ya-Li Zhang

Mechano-Chemical Coordination of Nanoparticle-Based Artificial Antigen-Presenting Cells Synergistically Tunes T Cell Activation and Expansion Phenotypes.

Particle-based artificial antigen-presenting cells (aAPCs) are widely used for ex vivo T cell activation, but rigid, high-avidity stimulation can promote differentiation and exhaustion, reducing therapeutic efficacy. Because T cells sense mechanical forces through the T cell receptor, we engineered nanocapsule aAPCs wi...