Ya-Man Zhang

Discovery of a fluorinated benzoxathiazine AMPA receptor PAM that stabilizes the GluA2 dimer interface and displays antidepressant-like effects.

Positive allosteric modulators (PAMs) of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors hold significant therapeutic promise for neuropsychiatric disorders driven by synaptic dysfunction. Building upon our previously established oxathiazine-dioxide scaffold, we designed and synthesized a novel se...