Abstract The mechanosensitive ion channel Piezo1 translates physical cues from the tumor microenvironment—including extracellular matrix stiffness, fluid shear stress, and compressive forces—into intracellular calcium signals and downstream cascades, playing a pivotal role in cancer. Piezo1 exhibits pronounced tumor-ty...
Hai-Yan Jiang, Ying Liu, Fei Xue et al.· Drug Design, Development and...· 0 citations
Abstract Breast cancer heterogeneity and its complex tumor microenvironment (TME) are key drivers of therapeutic failure and multidrug resistance (MDR). Drug delivery systems (DDS) provide an important approach, but their clinical translation remains limited by biological variability, formulation complexity, and manufa...
Gui-Wen Liang, Chu-Lin Zhu, Hua-Lin Sun et al.· Drug Design, Development and...· 0 citations
Skeletal muscle repair after injury depends on a tightly coordinated cascade of inflammatory and regenerative responses. Damage-associated molecular patterns (DAMPs) link tissue damage to innate immune activation, but their effects are highly context dependent. This review summarizes the major cellular sources of DAMPs...
Zi-Hui Gao, Xia Li, Ya-Nan Ji et al.· Biochemical Pharmacology· 0 citations
Current mechanistic insights inspire targeted therapeutic strategies comprising α-synuclein inhibitors, mitochondrial protectants, anti-inflammatory agents, and novel cell death pathway blockers, alongside gut-brain axis interventions for PD, but these approaches face substantial challenges.
Abstract Amyotrophic lateral sclerosis (ALS) is a highly heterogeneous and fatal neurodegenerative disorder, for which clinical management and drug development have long faced formidable challenges. Since the approval of riluzole and edaravone, dozens of promising drug candidates that showed efficacy in preclinical mod...
Yutong Wei, Jie Wang, Ya-Nan Ji et al.· Drug Design, Development and...· 0 citations
Post-traumatic stress disorder (PTSD) is a profound neurobiological disorder in which dysregulation of the neuroendocrine system represents a core pathophysiological feature. This Review synthesizes recent advances in PTSD neuroendocrine research to delineate a comprehensive and dynamic pathological landscape that exte...
Xia Li, Yanbei Zhu, Ya-Nan Ji et al.· Biochemical Pharmacology· 0 citations
Receptor-interacting protein kinase 3 (RIPK3) is classically recognized as a central executor of necroptosis, but accumulating evidence indicates that its functions extend beyond lytic cell death. RIPK3 regulates metabolic processes, inflammatory signaling, organelle homeostasis, and stress responses through both kinas...
Yun-Tian Shen, Haiyan Jiang, Jie Wang et al.· Biochemical Pharmacology· 0 citations
The molecular mechanisms underlying major cell death pathways are summarized and their context-dependent roles in skeletal muscle physiology are discussed, including development, adaptation, regeneration, and aging, as well as in disease progression.
Jiahuan Gong, Hong-Yi Xu, Yun-Tian Shen et al.· European Journal of Pharmaco...· 4 citations
The mechanisms of cGAS-STING activation in aging-including mitochondrial DNA leakage, nuclear envelope disruption, and retrotransposon activation-and its role in driving cellular senescence and the senescence-associated secretory phenotype (SASP) are reviewed.
Yutong Wei, Sutong Cai, Ya-Nan Ji et al.· Biochemical Pharmacology· 4 citations
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