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Author

Ya-Nan Wang

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Open access Oct 2026

Vitamin K3 (Menadione) Targets TBK1 to Enhance the Efficacy of Pirfenidone in a Mouse Model of Bleomycin-Induced Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible interstitial lung disease. Current antifibrotic drugs, exemplified by pirfenidone (PFD), only slow disease progression with limited efficacy and adverse effects, underscoring the need for novel therapeutic strategies. By integrating single-cell trans...

Ya-Nan Wang, Jun-Xian Cao, Yi Zhou et al. · 0 citations
Open access Oct 2026

SaCas9-Mediated CrtYB Disruption Coupled with Heterologous α-Bisabolol Production in Rhodotorula mucilaginosa JY1105

Rhodotorula mucilaginosa is a promising host for terpene biosynthesis, but its rational engineering remains constrained by limited genome-editing tools. Here, we developed a Staphylococcus aureus Cas9 (SaCas9) workflow in R. mucilaginosa JY1105 for CrtYB disruption and demonstrated heterologous α-bisabolol production....

Wen-Yi Sun, Hao-Yang Liu, Ya-Qi Dong et al. · 0 citations

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