Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible interstitial lung disease. Current antifibrotic drugs, exemplified by pirfenidone (PFD), only slow disease progression with limited efficacy and adverse effects, underscoring the need for novel therapeutic strategies. By integrating single-cell trans...
Ya-Nan Wang, Jun-Xian Cao, Yi Zhou et al.· International Journal of Mol...· 0 citations
Rhodotorula mucilaginosa is a promising host for terpene biosynthesis, but its rational engineering remains constrained by limited genome-editing tools. Here, we developed a Staphylococcus aureus Cas9 (SaCas9) workflow in R. mucilaginosa JY1105 for CrtYB disruption and demonstrated heterologous α-bisabolol production....
It is indicated that Astragalus polysaccharide alleviates IS-induced brain injury via the microbiota-gut-brain axis and LPS levels were upregulated in clinical patients with IS.
Yu Li, Jing Zhang, Shuo Li et al.· Chinese Journal of Natural M...· 0 citations
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