Ya-Qin Li

Shikonin Attenuates Neuroinflammation and Depression-Like Behaviors by Regulating Microglial Polarization Through Inhibiting cGAS-STING/NF-κB Signaling and Lipid Droplet Accumulation.

BACKGROUND Major depressive disorder is a disabling psychiatric illness with a growing global burden. Neuroinflammation, particularly microglial polarization, is increasingly recognized as a key pathogenic factor and is closely linked to lipid metabolic regulation. Shikonin, a bioactive naphthoquinone from Lithospermum...