Dissolving Microneedles Loaded with Lipid Nanoparticles for Co-Delivery of siTNF-α and Dexamethasone as a Dual-Action Therapy for Psoriasis.
Psoriasis, a chronic inflammatory skin disease, presents treatment challenges including systemic side effects and inadequate topical drug delivery. Herein, we developed a hyaluronic acid (HA)-based dissolving microneedle platform delivering tumor necrosis factor-alpha (TNF-α)-targeting small interfering RNA (siRNA) and...