Open access
Oct 2026
Mechanistic Decoding of Pharmacodynamic Intratumoral Heterogeneity: A Pan-Cancer Regulatory Framework
Zhi-Xiang Ren, Yi-Ming Ren, Ze-Ting Li et al.
· bioRxiv · 0 citations
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Open access
Jul 2026
Phenotype-driven de novo molecular design from gene expression signatures
Tx2Mol is presented, a transcriptome-guided framework that translates gene-expression signatures into candidate molecules while maintaining biological guidance throughout generation and support gene-expression phenotypes as actionable guidance signals for phenotype-directed molecular design and candidate prioritization...
Ya-Xin Xu, Taojie Kuang, Shuang Ge et al.
· bioRxiv · 0 citations