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Review Open access Oct 2026

ERK5 Signaling and Ferroptosis in Bone Homeostasis: Emerging Connections and Therapeutic Perspectives

It is proposed that ERK5 may shift the threshold between adaptive survival and ferroptotic injury in a cell-, stress-, and disease-stage-dependent manner, providing a testable framework for skeletal degeneration and regeneration.

Jiang-Ying Zhang, Xi-Ping Dou, Hao-Chuan You et al. · 0 citations
Review Open access Sep 2026

Artesunate in Ferroptosis and Cuproptosis Regulation: Context-Dependent Mechanisms, Interplay, and Therapeutic Implications

The discovery of ferroptosis and cuproptosis has significantly expanded the landscape of programmed cell death. Artesunate (ART), a semisynthetic derivative of artemisinin, exhibits pleiotropic pharmacological activities beyond its canonical antimalarial role, including anticancer and neuroprotective effects. However,...

Kai Feng, Ya-Yi Xia, Jing-Sheng Liu et al. · 0 citations

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