Author

Yadira M. Soto-Feliciano

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Open access Sep 2026

Paternal regulation of H3K4 methylation supports tumor suppressor networks in mammals intergenerationally

Paternally-inherited epigenetic information can influence phenotype in offspring (1). Here, we identify a critical mechanistic contribution of KDM6A (UTX), an X-linked histone modifier and tumor suppressor, in regulating transmissible epigenetic information in mammalian sperm. Paternal loss of KDM6A increases cancer ri...

B. W. Walters, Rachel A. Heuer, Haoming Yu et al. · bioRxiv · 0 citations

Open access Jul 2026

Epigenetic Reactivation of Lineage Differentiation to Target Leukemia

A selective small-molecule TRIM28 inhibitor is developed that binds the TRIM28 PHD-bromodomain, phenocopies TRIM28 loss across biochemical and cellular assays, exhibits low micromolar anti-leukemia activity, induces neutrophil differentiation, and synergizes with Menin inhibition.

Shandon M. Amos, Chi-Chao Chen, Yichen Xiang et al. · bioRxiv · 0 citations