Yan Chen

A pontomesencephalic-mesolimbic circuit modulates activity-based anorexia

Anorexia nervosa (AN) is a psychiatric disorder with a high mortality rate. The compulsive nature of the disorder leads to an emerging dopamine (DA)–centered hypothesis. However, the circuit mechanism of AN remains elusive. By examining a pontomesencephalic-mesolimbic circuit, which is implicated in anorexia-like and r...