Review
Open access
Aug 2026
Small-molecule inhibitors targeting the NLRP3 inflammasome: advances since mid-2023 and future perspectives.
The nod-like receptor protein 3 (NLRP3) inflammasome, a critical component of the innate immune system, governs the release of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and IL-18 and thereby plays a central role in the pathogenesis of various inflammatory diseases. Its aberrant activation is closely lin...
D. Jia, Yun-Lei Hou, Yue Wu et al.
· RSC Medicinal Chemistry · 0 citations