Ischemic stroke is a leading cause of mortality and long-term disability worldwide, yet the clinical efficacy of reperfusion therapies remains severely constrained by a narrow therapeutic time window and secondary ischemia-reperfusion injury. Preserving the viability of the ischemic penumbra through early, multi-target...
Xu-Rui Gu, Sai Wang, Lei Chen et al.· Journal of Controlled Releas...· 0 citations
This review systematically examines the intricate regulatory network of cellular senescence, encompassing multiple pathways including telomere dysfunction, DNA damage response, epigenetic remodeling, hormone signaling, and metabolic reprogramming, and integrating such strategies with conventional therapies holds promis...