Cell-resolved testing of network-pharmacology candidates in dilated cardiomyopathy: PI3K–AKT-associated transcriptional differences are distributed across cardiac lineages and are not enriched above a genome-wide background
Network pharmacology nominates targets but cannot show that they are altered in the relevant cell, distinguishable from a hypothesis-free analysis of the same data, or linked to disease. Taking the candidates nominated for Yangxin Decoction in dilated cardiomyopathy (DCM) and viral myocarditis, we asked how many surviv...