Single-cell transcriptomic analysis reveals systemic immune dysregulation and identifies PLEK as a candidate hub gene associated with CD8+ T-cell activation in myasthenia gravis.
Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody-mediated neuromuscular dysfunction, but the systemic immune landscape and underlying mechanisms remain unclear. Here we analyzed single-cell RNA-seq data from peripheral blood mononuclear cells of MG patients and healthy controls to characterize...