Author

Yan-Lian Yang

3 papers indexed here

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Open access Aug 2026

The Acidic Exosomal miR-1246/WASF3 Axis Regulates Hepatic Stellate Cell Activation and Stiff ECM Remodeling to Promote Pancreatic Ductal Adenocarcinoma Liver Metastasis

Liver metastasis is a major factor contributing to the poor prognosis of pancreatic ductal adenocarcinoma (PDAC). The formation of pre-metastatic niche (PMN) initiates the process of liver metastasis. Exosomes (Exos) act as key mediators of crosstalk between the tumor microenvironment (TME) and the PMN to activate hepa...

Dong-Qi Li, Xiang-Yu Chu, Fu-Sheng Zhang et al. · International Journal on Bio... · 0 citations

Aug 2026

A Dual-Action CXCR4-Targeted Peptide−Drug Conjugate Engineered to Enhance Antitumor Efficacy and Mitigate Myelosuppression in Pancreatic Cancer

Gemcitabine (GEM) is a first-line therapeutic option for pancreatic cancer; however, it has low efficacy due to rapidly developed drug resistance and severe dose-limiting myelosuppression. To enhance its therapeutic effect, this study developed a novel peptide−drug conjugate using a CXCR4 antagonistic peptide as the...

K. Zhu, Xuanxin Liu, Dapeng Li et al. · Molecular Pharmaceutics · 0 citations

Aug 2026

Impact of Phosphorylation on the Conformational Landscape and Aggregation Behavior of Aβ40: A Comprehensive Computational Study.

Phosphorylation of amyloid-β (Aβ40) at Ser8 and Ser26 exerts opposing effects on fibril formation: Ser8 phosphorylation promotes aggregation, whereas Ser26 phosphorylation strongly inhibits it. Using replica exchange with solute tempering (REST2) simulations and coarse-grained modeling, we reveal the atomic-level mecha...

Zai-Hang Ye, Chen Wang, Bin Tu et al. · Journal of Physical Chemistr... · 0 citations