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Open access Sep 2026

Air Pollution Triggers Metabolomic Signature of Mitochondrial Dysfunction in Mice and Humans: Implications for Cardiovascular Disease Development

Background: Previous animal studies found that subchronic exposure to diesel exhaust (DE) induces hyperlipidemia, accompanied by upregulation of 12- and 15-lipoxygenase (LOX) pathways and hepatic mitochondrial dysfunction. However, the human relevance of these findings has not been established. Methods: We studied ApoE...

Yan Lin, Xing-Hua Qiu, Rajat Gupta et al. · 0 citations
Aug 2026

Respiratory and Cardiovascular Effects of Ozone Modified by PM2.5: Evidence from a Panel Study and a Meta-Regression Analysis.

Disease burden of ground-level ozone (O3) may be underestimated partly due to unresolved inconsistencies in O3 health effects reported in the literature. Inaccurate exposure assessment, copollutant confounding, and other methodological issues have not fully explained the inconsistencies. To explore an alternative expla...

Shiyu Zhang, Yuehan Chen, Ke-Heng Xiang et al. · 0 citations

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