Author

Yan-Lin Zhao

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Review Open access Aug 2026

TBpop: an open-access portal integrating genomic variation, population genetic statistics, phylogeny, pangenome composition, and strain metadata of Mycobacterium tuberculosis isolates from a population-representative survey in China

Tuberculosis remains a major global public health threat. While whole-genome sequencing has transformed our understanding of the causative agent, Mycobacterium tuberculosis (MTB), existing genomic databases are highly fragmented and often underrepresent structural variations (SVs). Furthermore, critical population-gene...

Yang Zhou, Fei Huang, Yan-Lin Zhao · bioRxiv · 0 citations

Review Open access Aug 2026

Algorithmic Determinants of Performance Heterogeneity in Whole-Genome Sequencing-Based Prediction of Drug Resistance in Mycobacterium tuberculosis: A Systematic Review and Meta-Analysis

WGS-based bioinformatic tools provide highly specific and generally sensitive predictions of Mycobacterium tuberculosis resistance for first-line drugs across diverse clinical settings and should use prospective head-to-head evaluations on shared, geographically diverse isolate collections, alongside continued improvem...

Baozhen Peng, Yang Zhou, Xiang-Chen Li et al. · Microorganisms · 0 citations