Adolescent major depressive disorder (MDD) is characterized by marked clinical heterogeneity and heightened sensitivity to psychosocial adversity, particularly childhood trauma. Ongoing neurodevelopment and brain plasticity during adolescence may limit the applicability of adult-derived neurobiological models. Pr...
Xuan Liu, Ye-Xian Zeng, Xiao-Feng Lan et al.· BMC Psychology· 0 citations
BACKGROUND
Accumulating evidence implicates peripheral inflammation and glymphatic dysfunction in adult major depressive disorder (MDD), but whether glymphatic impairment exists in adolescent MDD and how it interacts with systemic inflammation remains unknown.
METHODS
Data were derived from the Symptomatic Trajectory...
Anhedonia, a prominent symptom of major depressive disorder (MDD), severely impairs patients’ quality of life and is challenging to treat. Although esketamine has shown potential in treating anhedonia in adult treatment-resistant MDD, its effects on adolescents remain under-explored.
In this study, a prosp...
Qian-Qian Wu, Wei-Cheng Li, Zhan-Jie Luo et al.· BMC Psychiatry· 0 citations
Efficient auditory attention requires prioritizing target over nontarget information. Although attentional deficits are a core feature of attention-deficit/hyperactivity disorder (ADHD), the neural mechanisms underlying auditory prioritization during cross-modal attention remain unclear. We examined neural differentiat...
The FCND-guided target framework provides a personalized, mechanism-informed strategy for precision neuromodulation in MDD and is statistically consistent with the hypothesis that distance influences improvement through Z-score normalization in the active group, with a directionally consistent trend in the iTBS dataset...
Zhan-Jie Luo, Wei-Cheng Li, Guanxi Liu et al.· Biological Psychiatry· 0 citations
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