Author

Yan Liu

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Review Open access Jul 2026

Circadian–immune crosstalk in insomnia disorder: mechanisms and therapeutic implications

Altered alterations in sleep–wake rhythms, melatonin signaling, HPA-axis activity, autonomic regulation, and immune-inflammatory responses in ID are summarized, and potential intervention strategies are discussed.

Yini Huang, Xiuying Wang, Xiang-Jiao Chen et al. · Frontiers in Neuroscience · 0 citations

Review Open access Jul 2026

Circadian dimensions in insomnia disorder: mechanistic evidence, candidate phenotypes, and a phenotype-stratified research framework

A candidate circadian phenotyping framework for insomnia disorder is proposed and combines sleep diaries, actigraphy, light exposure assessment, dim-light melatonin onset (DLMO), and core body temperature rhythms to distinguish circadian rhythm sleep-wake disorder (CRSWD)-dominant insomnia complaints, insomnia disorder...

Shasha Zhang, Yan Liu, Jin-Zhi Tan et al. · Frontiers in Psychiatry · 0 citations