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Open access Oct 2026

A Robust Bio-Supportive Hydrogel Patch for Full-Thickness Repair of Gastroesophageal Defects.

Surgical repair of gastroesophageal (GE) defects is a formidable clinical challenge, plagued by high leakage, fistula recurrence and life-threatening complications due to gastric acid exposure and persistent mechanical stress. To address this unmet need, we developed a robust bio-supportive (RBS) hydrogel patch for imm...

Xing-Qi Song, Zhe-Wei Shuai, Wei-Yan Sun et al. · 0 citations
Open access Aug 2026

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

This study investigated how lactylation in histone H3 at lysines 9, 18, and 27 modulates PANoptosis in SA‐AKI and identified DEAD (Asp‐Glu‐Ala‐Asp)‐box helicase 3x (DDX3x), a previously unreported delactylase capable of regulating H3K9/18/27la levels, which influences NINJ1 transcription and PANoptosis.

Hong-Yu Liang, Jihong Jiang, Huan-Xin Yin et al. · 0 citations

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