Author

Yan Luo

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Review Open access Sep 2026

Radioiodine-induced cGAS-STING signaling and antitumor immunity in thyroid cancer

Radioiodine (RAI) is a cornerstone of treatment for differentiated thyroid cancer (DTC), yet the immunological consequences of RAI-induced DNA damage remain poorly understood. Here, we examine cGAS–STING signaling as a potential mechanistic link between RAI-induced genotoxic stress and antitumor immunity. RAI delivers...

Feng Gao, Dao-Ming Zhang, Yan Luo et al. · Frontiers in Immunology · 0 citations

Open access Oct 2026

Association of early dynamic changes in peripheral blood immune-inflammatory indices with subsequent acquired resistance to immune checkpoint inhibitors in advanced non-small cell lung cancer: a landmark analysis.

BACKGROUND Acquired resistance to immune checkpoint inhibitors (ICIs) remains a major challenge in advanced non-small cell lung cancer (NSCLC). This study evaluated whether early dynamic changes in peripheral inflammatory and nutritional indices predict subsequent acquired resistance. METHODS This retrospective landm...

Li-Po Song, W. Lv, Qing-Bo Wang et al. · Immunotherapy · 0 citations