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Yan-Qi Song

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Review Open access Sep 2026

Immune remodeling of tumor-draining lymph nodes: mechanistic determinants of checkpoint blockade responsiveness

Remodeling of tumor-draining lymph nodes (tdLNs) can precede overt nodal metastasis and has emerged as a determinant of immune checkpoint blockade (ICB) responsiveness. Sustained lymphatic delivery of tumor-derived antigens, extracellular vesicles, cytokines, and metabolites perturbs stromal and vascular programs, in...

Cai-Yan Jia, Shu-Xuan Li, Mu-Hua Chen et al. · 0 citations

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