Integrative Machine Learning and Single-Cell RNA Sequencing Reveals Timp1+ Stromal Cells as Key Drivers in Ulcerative Colitis
Background Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease (IBD). The role of stromal cells in UC pathogenesis is increasingly being recognized, yet their functional subsets and underlying molecular mechanisms remain poorly defined. Objective To integrate multiple transcriptomic datasets, comb...