The proto-oncogene KRAS is mutated in greater than 90% of pancreatic ductal adenocarcinoma (PDAC). Although newly developed multi-RAS(ON) inhibitors (daraxonrasib) have significantly improved progression-free and overall survival compared with current standard-of-care chemotherapy in PDAC patients, both clinical and...
Cassandra S. Markham, Ilze M. Olivi Gomes, Yi Di et al.· Cancer Research· 0 citations
Transcriptional elongation undergoes extensive remodeling at mitotic entry, yet how elongation control is integrated into core cell-cycle kinase networks remains unclear. Here, we identify the m6A methyltransferase METTL3 as a direct substrate of the mitotic kinase CDK1 in mammalian cells. CDK1-dependent phosphorylatio...
Azime Akçaöz-Alasar, Yanhua Wang, Hang Li et al.· Molecules and Cells· 1 citation
This study establishes a comprehensive multi-omics resource for KRAS signalling in PDAC and demonstrates that cellular context exerts a stronger influence than allele identity in shaping molecular profiles, with implications for interpreting putative allele-specific signalling dependencies.
Yanixa Quiñones-Avilés, Barbora Šalovská, Cassandra S. Markham et al.· Molecular Omics· 0 citations
A multi-omics framework that infers context-specific protein activities from transcriptomic, phosphoproteomic, and protein correlation-based protein-protein interaction data is introduced, integrating modality-specific algorithms via network diffusion.
George A. Rosenberger, Peng Xue, Isabell Bludau et al.· Molecular Systems Biology· 0 citations
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