Exacerbation of renal interstitial fibrosis by the UHRF1/G9a axis through epigenetic silencing of KLF15
Abstract Renal fibrosis represents a central pathological driver of chronic kidney disease (CKD), yet the epigenetic mechanisms remain incompletely understood. This study identifies a critical role for the Ubiquitin-like with PHD and RING Finger domains 1 (UHRF1)/G9a axis in this process. We demonstrated that both UHRF...